Floxuridinum [Inn-Latin]

Floxuridinum [Inn-Latin] Brand names, Floxuridinum [Inn-Latin] Analogs

Floxuridinum [Inn-Latin] Brand Names Mixture

No information avaliable

Floxuridinum [Inn-Latin] Chemical_Formula

C₉H₁₁FN₂O₅

Floxuridinum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic2/floxuridine.htm

Floxuridinum [Inn-Latin] fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=floxuridine%20(intraarterial)

Floxuridinum [Inn-Latin] msds (material safety sheet)

Floxuridinum_[Inn-Latin] MSDS

Floxuridinum [Inn-Latin] Synthesis Reference

No information avaliable

Floxuridinum [Inn-Latin] Molecular Weight

246.193 g/mol

Floxuridinum [Inn-Latin] Melting Point

150.5 ^oC

Floxuridinum [Inn-Latin] H₂O Solubility

1.19E+004 mg/L

Floxuridinum [Inn-Latin] State

Solid

Floxuridinum [Inn-Latin] LogP

-1.249

Floxuridinum [Inn-Latin] Dosage Forms

Powder for solution (500mg vial)

Floxuridinum [Inn-Latin] Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Floxuridinum [Inn-Latin] Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Floxuridinum [Inn-Latin] Absorption